IMMUNOLOGIC INCOMPETENCE OF IMMUNOLOGICALLY RUNTED ANIMALS

Immunologic Incompetence of Immunologically Runted Animals

1. Adult (A x C(57)Bl/1)F(1) hybrids regularly show runt disease when injected with adult spleen cells from A strain donors. This also occurs when A strain spleen cells are administered to adult C(3)H mice made tolerant of A strain tissue in the neonatal period. 2. Mice undergoing the graft versus host reaction fail to form antibodies to an intraperitoneal challenge of T(2) bacteriophage. This ...

What Is Immunologic Competence? an Attempt to Define the Attributes of the Immunologically Functioning Cell.

Host and tumor modifications associated with serial heterotransplantation of tumors through immunologically tolerant animals.

Adenovirus-mediated delivery of fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals.

BACKGROUND Adenoviral constructs have been used for studies of injury-induced vascular hyperplasia in immunologically naive laboratory animals, but their usefulness for intra-arterial gene therapy may be limited by the prevalence of preexisting immunity to adenovirus in the patient population. Here, we explored the efficacy of adenovirus-mediated transfer of Fas ligand, a cytotoxic gene with im...

Perforator incompetence. Case of perforator incompetence--making SEPS better.